By Kevin D. Altria (auth.)
During the 1980's the research of prescription drugs was once ruled via excessive Perfor mance Liquid Chromatography (HPLC). different separative strategies akin to fuel Chromato graphy and skinny Layer Chromatography provided choices yet their quantitative capabili ties and/or solute diversity couldn't procedure that of HPLC. nearly all of prescribed drugs are ionic and it'd be average to imagine that electrophoresis might be priceless within the research of prescribed drugs. besides the fact that, the electrophore tic tools to be had within the 1980's have been labour in depth and hired post-separation detection strategies. throughout the overdue 1980's and early 1990's wide learn was once con ducted into the probabilities of carrying out electrophoretic separations in capillaries. This method allowed online detection and will be played on absolutely computerized gear. This examine resulted in the appearance of contemporary day capillary electrophoresis (CE) tools which supply comparable functionality and automation degrees to that of HPLC. study used to be additionally involved in constructing functions for CE and specific recognition was once paid to functions in the pharmaceutical research quarter. those purposes proved that CE should be utilized to a variety of drug varieties together with water insoluble and impartial compounds. the facility to accomplish effective chiral separations of substances additionally elevated the recognition of the process. CE with oblique UV detection has develop into confirmed as an easy and powerful replacement to ion-exchange chromatography for the decision of small inorganic or natural ions.
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Extra info for Analysis of Pharmaceuticals by Capillary Electrophoresis
The samples were prepared in 60:40 acetonitrile: water. 2 Reported Applications six tablets using the method. 87 %. Alternatively (1) samples of water-insoluble basic drugs can be prepared in acidic solutions in which they are protonated. Often a 1: 10 dilution of the separation electrolyte produces a solution with a sufficiently low pH to solubilise water-insoluble compounds. Alternatively if the compound also possesses an acidic function, it may be possible to dissolve the compound in dilute NaOH and analyse using a low pH electrolyte (11).
14 (1991) 973-986. 30. Nishi H, Fukayama T, Matsuo M and Terabe S, Separation and determination of lipophilic corticosteroids and benzothiazepin analogues by micellar electrokinetic chromatography with bile salts, J. , 513 (1990) 279-295. 31. Bumgarner J G and Khaledi M G, Mixed micellar electrokinetic chromatography of corticosteroids, Electrophoresis, 15 (1994) 1260-1266. 32. Jumppanen J, Siren Hand Riekkola M L, Screening for diuretics in urine and blood serum by capillary zone electrophoresis, J.
Although the compound of interest to each reader may not be included there are many examples and references throughout the text which may steer readers in the right direction. References 1. Jorgenson J Wand Lukacs K D, Zone electrophoresis in open-tubular glass capillaries, Anal. , 53 (1981) 1298-1302. 2. Li SFY, in Capillary Electrophoresis, principles, practice and applications, Elsevier press, 1992. 3. Kuhn R and Hoffstetter-Kuhn, in Capillary Electrophoresis: Principles and Practice, SpringerVerlag Press, Berlin, 1993.